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dc.contributor.authorFalfushynska, Halina-
dc.contributor.authorGnatyshyna, Lesya-
dc.contributor.authorHoryn, Oksana-
dc.contributor.authorSokolova, Inna-
dc.contributor.authorStoliar, Oksana-
dc.date.accessioned2018-05-23T07:59:39Z-
dc.date.available2018-05-23T07:59:39Z-
dc.date.issued2017-
dc.identifier.citationFalfushynska, H. Endocrine and cellular stress effects of zinc oxide nanoparticles andnifedipine in marsh frogs Pelophylax ridibundus / Halina Falfushynska, Lesya Gnatyshyna, Oksana Horynb [et al.]. // Aquatic Toxicology. – 2017, vol. 185. – P. 171-182.uk_UA
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166445X17300401-
dc.identifier.urihttp://dspace.tnpu.edu.ua/handle/123456789/9059-
dc.description.abstractFreshwater organisms including amphibians experience increasing exposures to emerging pollutants such as nanoparticles and pharmaceuticals, which can affect their fitness and performance. We studied the effects of two common pollutants extensively used in industry, pharmaceutical and personal care products, nano-zinc oxide (nZnO) and a Ca-channel blocker nifedipine (Nfd), on endocrine status and cellular stress markers of the marsh frog Pelophylax ridibundus. Males were exposed for 14 days to nZnO (3.1 μM), Zn2+ (3.1 μM, as a positive control for nZnO exposures), Nfd (10 μM), and combination of nZnO and Nfd (nZnO+Nfd). Exposure to nZnO and Zn2+ led to an increase in Zn burdens, elevated concentrations of the metal-bound metallothioneins (MT-Me) in the liver and increased vitellogenin in the serum, whereas exposures to Nfd and nZnO+Nfd resulted in the metal release from MTs and a significant increase in the ratio of total to metal-bound MTs. This likely reflects oxidative stress caused by Nfd exposures as manifested in the elevated levels of oxyradical production, upregulation of superoxide dismutase activity (SOD) and increase in the total and oxidized glutathione concentrations in Nfd-exposed frogs. Zn-containing exposures upregulated activity of deiodinase (in nZnO and nZnO+Nfd exposures) and serum thyrotropin level (in the case of Zn2+). All exposures caused an increase in DNA fragmentation, lipofuscin accumulation as well as upregulation of caspase-3 and CYP450 levels reflecting cytotoxicity of the studied compounds in the liver. Across all experimental treatments, nZnO exposures in the absence of Nfd had the least impact on the cellular stress traits or redox status in frogs. This indicates that at the low environmentally relevant levels of pollution, pharmaceuticals such as Nfd and free metals (such as Zn2+) may represent a stronger threat to the health of the frogs than nZnO particles.uk_UA
dc.language.isoenuk_UA
dc.subjectamphibiansuk_UA
dc.subjectnano-zinc oxideuk_UA
dc.subjectpharmaceuticaluk_UA
dc.subjectmetallothioneinuk_UA
dc.subjectendocrine systemuk_UA
dc.subjectcytotoxicityuk_UA
dc.titleEndocrine and cellular stress effects of zinc oxide nanoparticles and nifedipine in marsh frogs Pelophylax ridibundusuk_UA
dc.typeArticleuk_UA
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